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This is in agreement, some studies showing no sex differences in total IGF1 25 or free IGF1 levels through development 74 , but not with others 24 , Diabetes Metab Syndr Obes. Fukuda, I. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Diabetes Metab. Our findings establish a potentially new role of the alternative complement pathway in adaptive thermogenesis and highlight sex-specific considerations in potential therapeutic targets for metabolic diseases. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Fig 7. Click through the PLOS taxonomy to find articles in your field. The threshold for significance for the eQTLs was set to 2. Within diet comparison groups one and two, no significant differences in mean percent lipid content were observed for either sex Fig 4. The Friendly Side of Fat.
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